Solution Science for Research and Industry

Posts tagged “fluorescence

CRAIC’s Technologies MP-2™ Photometer can upgrade your microscope

The CRAIC Technologies MP-2™ Microscope Photometer is designed to add photometry and imaging to an optical microscope. With a spectral range from the deep UV to the near infrared, the MP-2™ is better described as a microscope radiometer. It is limited only by the microscope’s optics.

The CRAIC MP-2™ microphotometer enables collection of transmission, reflectance or even fluorescence and luminescence photometric data of microscopic samples.

mp-1The MP-2’s solid state detectors have dynamic ranges and sensitivities greater than PMTs or imaging systems and with complete software control, either broad- or narrow-band, photometric intensity measurements can be made. Typical applications include:

  • Cytophotometry & immunohistochemistry
  • Cytofluorimetry & immunofluorescence
  • Intracellular calcium measurements
  • Gemology & mineralogy
  • Thickness measurements
  • Ion & pH measurements
  • DNA analysis
  • Photoreceptor analysis

Please contact us for more details.

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New DuaLED Light Engine for UV-Visible from Prizmatix

Prizmatix’s self-contained UHP-M is an ultra-high power UV-Visible light source designed to replace Metal-Halide and Mercury lamp systems in many microscopy and fluorescence applications.

Incorporating two independently controllable Prizmatix large-chip LEDs, the UHP-M delivers broadband white from a single 55 W LED, and high power UV from a single 10 W LED operating at 365, 385 or 405 nm depending on model ordered. The UHP-M offers:

  • Optically isolated TTL & analogue inputs for each channel
  • Fast TTL switching
  • Low optical noise
  • Long life (no lamp replacement)
  • Fanless operation
  • Remote control*
  • USB interface*

uhp-m_withchart

* The UHP-M requires no external control if operating at full power. However, if power levels need to be adjusted, an optional remote control or USB interface will be required.


Bright products for Microscopy, Spectroscopy and Optogenetics

OLYMPUS DIGITAL CAMERAElliot Scientific distribute a comprehensive range of high powered LED light delivery products for microscopy, spectroscopy, optogenetics, and other scientific research and industrial applications. Manufactured by Prizmatix, a scientist-led company that specialises in the design and manufacturing of ultra high-power LEDs, a range of power levels and wavelengths across the spectrum are available for applications that include…

  • For microscopy and imaging: the powerful UHP-T LED series
  • For optogenetics: single and dual wavelength systems for in-vivo and in-vitro research
  • For custom setups:
    • offering modularity and versatility
    • fibre-coupled units with up to 11 different LEDs

STSI-All-250-1For in-vivo and in-vitro optogenetics, Prizmatix offer a full range of modules that start from single wavelength plug-and-go kits, to multi-wavelength systems for activation and silencing in the same fibre. From light sources to cannulae, and everything in between, Prizmatix provides all the components necessary for experimenters in neuroscience, neurobiology, electrophysiology, biochemistry and biophysics. Typical systems have been constructed by researchers for:

  • Detection & excitation
  • Intensity monitoring
  • In-line filtering, attenuation or polarisation
  • Reflectance or fluorescence detection for in situ, in-vivo, or in-vitro applications

Prizmatix have extensively developed various photonics products for use in neuro and bioscience research such as optogenetics, as well as traditional chemistry, biology and physics. For example, fluorescence and Raman spectroscopy, microscopy, and absorption measurement are typical applications here. Elliot Scientific are always happy to advise, so contact us today for further information.


UHP-T-MP: Excellent for Optogenetics/fluorescence excitation in microplate applications

batch5-057The UHP-T-MP series of Ultra High Power LEDs, by Prizmatix, feature a powerful rectangular (3:4) homogeneous collimated beam useful in many demanding applications such as direct microplate illumination without a light guide, fluorescence microscopy and machine vision.

Optimal illumination of standard 96 well microplates from a working distance of about 40 cm is realised by its aspheric optics, and the USB-equipped LED controller supports CW or pulsed operation via a TTL trigger. LED intensity can be set via a pot or external analogue voltage input.

The UHP-T-MP is available in blue – 455 nm, green – 528 nm or red – 630 nm wavelengths, and can be used coupled to an optical fibre or liquid light guide, or just as a collimated light source.

Key features

  • Single chip Ultra High Brightness LED
  • Precisely adjustable, stable power
  • 3:4 aspect ratio
  • CW or pulsed operation
  • USB interface
  • Long life (no consumable parts)

For more information, please contact us.


Long-range Z-axis nanopositioning stage is especially designed to hold multiwell plates

The Mad City Labs‘ Nano-ZL Series are long range, Z-axis nanopositioners specifically designed to hold multiwell plates used in biomedical research. High-throughput single cell fluorescence microscopy and high speed, high resolution confocal imaging can be accomplished while simultaneously adjusting the Z-axis position to remove the effects of multiwell plate irregularities.

The Nano-ZL Series has true flexure guided motion and contains internal position sensing for a resolution of better than 1 nm over the full 500 µm travel range, and sub-nanometer for the shorter 100 µm travel range. In addition to high resolution spatial imaging, the Nano-ZL step response allows entire Z-section acquisitions with minimal photo bleaching. For more information, please contact us.


December 2015 Newsletter Out Now

December 2015 NewsletterThe Elliot Scientific December newsletter is now available. In this issue, Elliot Scientific and OZ Optics show off their glass-wares, Integrated Optics reveals the new MatchBox 2 series of compact lasers, Micro Laser Systems unveils new collimators for the SWIR waveband, Winter holidays and more.

To view it in a browser, click here.

To read it magazine-style online, click here.

To download it as a PDF, click here.


November 2015 Newsletter Out Now

November 2015 NewsletterThe Elliot Scientific November newsletter is now available. In this issue, new IPG fibre lasers, new THz-frequency contact probing from Lake Shore, New multi-channel temperature monitor from Neoptix, plus photoluminescence microspectroscopy from CRAIC Technologies and more.

To view it in a browser, click here.

To read it magazine-style online, click here.

To download it as a PDF, click here.


“MatoS & RandaS” are fresh, new SERS substrates cooked up by Ato ID

Ato ID has issued performance and application details for their next-generation of disposable glass substrates for Surface Enhanced Raman Spectroscopy (SERS) and/or Surface Enhanced Fluorescence (SEF).

The new smaller AtoID ‘MatoS’ gold and ‘RandaS’ silver Plasmonic Sensor Substrates are available in addition to the existing 1″ square ‘Randa’ and ‘Mato’ ranges and continue to deliver up to 8x more sensitivity than leading rivals.

These new ½” long small form factor slides are individually vacuum packed in 1.5 ml microcentrifuge tubes enabling easier handling for fresh, on-the-spot analysis of immersed material.

  • Size: 12.5 x 5 x 1 mm
  • Active area: 3 x 5 mm
  • Excitation wavelengths:
    • Silver RandaS: 442 nm to NIR
    • Gold MatoS: 600 nm to NIR

For extra information about these new SERS substrates from AtoID, please contact us.


New SERS/SEF substrates significantly enhance Raman signal

sers-substrate-glas_43The Ato ID™ Randa Plasmonic Sensor is designed to offer good results in both the visible and IR wavelength ranges for both Surface Enhanced Raman Spectroscopy (SERS) and Surface Enhanced Fluorescence (SEF).

Features

  • Ideal for visible and IR laser wavelengths
  • Significantly enhances Raman signal
  • Coated with 99.99% silver
  • Active area: 4 x 4 mm (typical)
  • Overall carrier size 25 x 25 x 1 mm thick
  • Compatible with use of cover slip over the active SERS area
  • Developed specifically for high sensitivity trace detection applications

The base substrate is soda-lime glass which exhibits relatively weak inherent Raman scattering and so does not interfere with the sample signal. The active region comprises a pure silver coating over the proprietary nanofabricated base (patent pending). The monolithic structure eliminates risk of contaminants that can arise with glued or chemically treated types. All ‘Randa’ Raman substrates are vacuum sealed in a cleanroom environment for ease of handling. Please contact us for more information.


Nine New Products from Mad City Labs

Mad City Labs has recently introduced eight new positioning systems to their already extensive range, and launched a total internal reflection fluorescence microscopy accessory in the form of the MicroMirror TIRF.

Nano-MET10 and Nano-MET20
Compact, high-speed, single axis nanopositioning systems with exceptional resonant frequency, ultra-low noise performance and picometre positioning resolutionNano-MET2 and Nano-MET3
Ultra-low noise, high-precision, high-speed XY and XYZ nanopositioning system with picometre positioning resolution

Nano-HS3M
High-speed, compact XYZ precision nanopositioning system with < 2 pm noise on all axes and picometre positioning resolution

Nano-METZ
Compact Z-axis nanopositioning system with ultra-fast response, picometre resolution, and femtometre noise floor for demanding scanning, AFM, and metrology applications

MCL-MANNZ
Integrated inverted optical microscope micro-nanopositioning system combining micrometer driven, two axis, linear motion stage with a high resolution, Z-axis nanopositioner

MCL-MOTNZ
Ultra-stable inverted optical microscope positioning system combining stepper motor XY linear motion stage with a high resolution Z-axis nanopositioning system

MicroMirror TIRF – Total Internal Reflection Fluorescence Microscopy Accessory
An enabling technology for advanced study of complex biomolecular interactions using a proven design that offers a simple yet flexible instrument platform for single molecule research

For the detailed specifications of these new nanopositioners or other products Mad City Labs offer, contact us now.


RM21™ Platform Offers Precision Framework for Custom Microscopy

Microscope Platform for the FutureThe RM21™, from Mad City Labs, is a precision microscope platform designed for maximum user accessibility. Its three dimensional space makes it the perfect framework for constructing custom microscopy instruments that require a flexible configuration. As all posts and fixturing points are referenced to a known datum, the microscopy and optical components used in the experiment are easily aligned.

Advanced applications, such as super resolution (SR) microscopy, fluorescence microscopy and TIRF, will all benefit from the RM21’s thoughtful design and robust construction. From now on, microscopy projects can leave the flat optical table for a 3D future. Contact us for more details about the RM21 and Elliot Scientific’s Lab Essentials range of optical fixtures and fittings.


Seven Nanopositioning Elements from Mad City Labs

Elliot Scientific has expanded its coverage of Mad City Labs equipment available through the company by adding a dedicated webpage for the Nano-F series of focusing elements. The new page details Mad City Labs’ offerings for microscopists involved in 4Pi microscopy, STORM, PALM, confocal and fluorescence imaging, super resolution (SR) microscopy, high speed Z stack imaging and other applications requiring high speed focus adjustment:

  • Nano-F Series – Objective lens focusing elements with 100 µm or 200 µm of travel
  • Nano-F25HS – A high speed nanopositioner focusing element with 25 µm travel
  • Nano-F3D  – An objective lens nanopositioner with 3-axis (XYZ) motion up to 100 µm per axis
  • Nano-F450  – The longest travel range piezo focusing element available for research microscopy with 450 µm travel

These elements can be used as stand-alone systems, or in conjunction with other Mad City Labs nanopositioning stages, and feature quick mount threaded adapters for RMS and metric lens threads.

In addition, we have also added the following nanopositioning stages to existing pages within the dedicated Mad City Labs section of their website:

  • Nano-MTA Series – A range of mirror tip/tilt actuators for rapid scanning of laser beams with sub-microradian resolution
  • Nano-OPH Series – A large central aperture nanopositioning stage with ranges of motion from 30 up to 100 µm
  • Nano-SPM200 – A compact nanopositioning system with 200 µm travel

For more information on these and the other piezo-driven stages Mad City Labs offer, please contact us or download the Mad City Labs 2012 Catalogue here.